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The Jupiter Study: New Crestor Trials
"The Jupiter study is the first to show that the most potent and recently introduced statin - rosuvastatin - reduces heart attacks and save lives, even in people whose cholesterol is not raised."
The Jupiter Study refers to a large trial that explored how Crestor (rosuvastatin), a currently prescribed statin, might benefit people with cholesterol levels lower than are currently treated.
While the results of the study do not apply to all people, as suggested in some newspapers, it will form the basis of further research and may change the way statins are prescribed in the future.
The results of this study are impressive, with the drug reducing relative risk of certain heart problems by 44%. It is important to note that while participants were 'lower risk' in terms of their cholesterol levels, they were still not 100% healthy. Everyone in this study had had high blood levels of a protein (called high-sensitivity C-reactive protein, or CRP) linked to cardiovascular problems.
In total 17,802 people were randomised to either treatment (rosuvastatin) or placebo. At the 12 month follow-up, rosuvastatin had significantly lowered LDL cholesterol, levels of CRP and triglyceride fats compared to the placebo.
The researchers concluded that rosuvastatin significantly reduced the occurrence of major cardiovascular events in people without high blood lipids (hyperlipidemia) but with elevated levels of high-sensitivity C-reactive protein levels.
In response to the findings of the study, Professor Peter Weissberg, Medical Director at the British Heart Foundation said:
"The findings raise questions about who should receive treatment to prevent a heart attack, how aggressively they should be treated and with which drug. These important issues have profound implications for future NICE guidelines."
"This research, adds to the body of evidence that statins work, and that the lower your cholesterol level, the lower your risk of a heart attack or stroke."
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